Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma
Promoter mutations in telomerase reverse transcriptase (TERT) and telomere length have been studied in various tumors. In the present study, the frequency and clinical characteristics of TERT promoter mutation and telomere length were studied in hepatocellular carcinoma (HCC). TERT promoter mutation and telomere length were analyzed in 162 tumor samples of the patients with HCC by sequencing an...
متن کاملTERT promoter mutation, telomere length, and TERT expression in gastric cancer
Objective: The mutation in the promoter region of telomerase reverse transcriptase (TERT) has been focused in various cancers. In present study, the frequency and clinical characteristics of TERT promoter mutation, telomere length, and TERT expression in gastric cancers were studied. Materials and Methods: We sequenced TERT promoter region in 104 gastric cancers. And telomere length and TERT ex...
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BACKGROUND Hepatocellular carcinoma (HCC), the main malignant tumor of the liver, is very common and highly lethal. The aim of this study was to determine its clinicopathologic characteristics and risk factors in Turkey. MATERIALS AND METHODS In this study, patients who were diagnosed as suffering from HCC in the period between August 2004 and December 2011 were evaluated retrospectively. R...
متن کاملThe TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma
Telomerase activation via induction of the catalytic component telomerase reverse transcriptase (TERT) plays essential roles in malignant transformation. TERT promoter-activating mutations were recently identified as a novel mechanism to activate telomerase in hepatocellular carcinoma (HCC) and many other malignancies. In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 an...
متن کاملTelomere Length, TERT, and miRNA Expression
It has been proposed that miRNAs are involved in the control of telomeres. We test that hypothesis by examining the association between miRNAs and telomere length (TL). Additionally, we evaluate if genetic variation in telomerase reverse transcriptase (TERT) is associated with miRNA expression levels. We use data from a population-based study of colorectal cancer (CRC), where we have previously...
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ژورنال
عنوان ژورنال: Medicine
سال: 2017
ISSN: 0025-7974
DOI: 10.1097/md.0000000000005766